Case Studies
Experimental Drug SS1(dsFv)-PE38 to Treat
Cancer:
Background:
This study will determine the dose of the experimental anticancer
drug SS1(dsFv)-PE38 that can be given safely to patients. It will
also look at how the body handles the drug, its side effects,
and its effect on the tumor. SS1(dsFv)-PE38 will be tried in patients
with solid tumors that have an antigen called mesothelin. This
is a protein that is normally produced by cells lining body cavities,
but has also been found on several types of cancer cells.
The drug SS1(dsFv)-PE38 is composed of SS1, a protein that binds
tightly to mesothelin, and PE38, parts of the Pseudomonas exotoxin
(PE) protein, which can kill human cells if it gains entry to
them. SS1(dsFv)-PE38 is designed to attach to mesothelin on the
cancer cells and allow entry of the PE38, which will then destroy
the cells.
Location/Contact Information:
Maryland
National Cancer Institute (NCI), 9000 Rockville Pike, Bethesda, Maryland,
20892, United States;
Recruiting
Clinical Studies Support Center/NCI 1-888-624-1937
ncicssc@mail.nih.gov
